Effect of insulin and insulin-like growth factor I on fetal macrosomia in healthy women.

The aim of the study was to determine the values of insulin, insulin-like growth factor I (IGF-I) and glucose in the umbilical cord blood of macrosomic (> or = 4000 g) and control (3,000-3,500 g) infants born to healthy mothers, and to assess their possible correlation with the newborns' birth weight and maternal anthropometric parameters. A series of 207 macrosomic term infants, and 200 control term infants, born to healthy mothers with normal oral glucose tolerance test throughout gestation, were studied. The glucose concentration did not differ between the macrosomic and control group while macrosomic infants had significantly higher values of insulin and IGF-I. Female macrosomic infants had significantly higher levels of insulin and IGF-I than male macrosomic infants. The levels of insulin and IGF-I, but not levels of glucose, differed between the macrosomic and control group according to the maternal weight, height, pregestational body mass index, weight gain during gestation, and maternal birth weight. The maternal anthropometric parameters were significantly greater in the macrosomic infants. Accordingly, macrosomia was concluded to be a multifactorial condition.